iTANK is a universal CAR/TCR T-cell enhancement technology platform that arms CAR/TCR T-cells with a pluripotent proinflammatory neutrophil- activating protein (NAP) from Helicobacter pylori, which induces bystander immunity via epitope spreading. Preclinical data, published in Nature Biomedical Engineering, have demonstrated:
Proof-of-concept data was published in Nature Biomedical Engineering in April 2022. Download the publication to learn more about iTANK, its mode of action and how it can enhance your immunotherapy research!
The success of CAR T-cell therapies has been remarkable in treatment of hematological cancers and has to date resulted in several market approved products for treating B-cell and plasma cell malignancies. However, no CAR T-cell therapy has yet been approved for treatment of solid tumors.
The two main challenges that CAR T-cell therapies face in the treatment of solid tumors are:
The iTANK-platform can help combat CAR-target-antigen heterogeneity and reduce immunosuppression within solid tumors improving CAR-T therapy outcomes. Contact us to learn more.
Based in Sweden, Elicera Therapeutics AB is a clinical stage immuno-oncology company developing next generation cell and gene therapies for immune-based cancer treatments.
In addition to the iTANK platform, Elicera is developing four drug candidates, two of which are in the field of oncolytic viruses and two in the field of CAR T-cell therapies. Please contact us via the form below with any enquiries.